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ERLOTINIB HCL SALT

Erlotinib hydrochloride

CAS: 183319-69-9

Molecular Formula: C22H24ClN3O4

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ERLOTINIB HCL SALT - Names and Identifiers

Name Erlotinib hydrochloride
Synonyms ERLOTINIB HCL
Erlotinib HCl
Erlotinib, OS-774
ERLOTINIB HCL SALT
Erlotinib hydrochloride
Erlotinib, Hydrochloride Salt
Tarceva HydrochlorideSee E625000
Tarceva Hydrochloride See E625000
quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine
[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine Hydrochloride
N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
N-(2-chloro-6-methyl-phenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methyl-pyrimidin-4-yl]amino]thiazole-5-carboxamide
CAS 183319-69-9
EINECS 620-491-0
InChI InChI=1/C22H23N3O4.ClH/c1-4-16-5-7-17(8-6-16)25-22-18-13-20(28-11-9-26-2)21(29-12-10-27-3)14-19(18)23-15-24-22;/h1,5-8,13-15H,9-12H2,2-3H3,(H,23,24,25);1H

ERLOTINIB HCL SALT - Physico-chemical Properties

Molecular FormulaC22H24ClN3O4
Molar Mass429.9
Melting Point223-225°C
Boling Point548.2°C at 760 mmHg
Flash Point285.4°C
Solubility Soluble in DMSO (3 mg/ml), methanol (sparingly), water (<1 mg/ml), and ethanol (<1 mg/m
Vapor Presure4.52E-12mmHg at 25°C
AppearanceYellow powder.
ColorWhite or off-white
pKapKa (25°): 5.42
Storage ConditionInert atmosphere,Store in freezer, under -20°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
UseHER-1 / EGFR tyrosine kinase inhibitor
In vitro studyErlotinib acts on HNS human head and neck tumor cells and effectively inhibits EGFR autophosphorylation. HNS human head and neck tumor cells are cell lines that express high levels of EGFR. Erlotinib had no effect on SBC-5 cell proliferation. In contrast, Erlotinib significantly inhibited PC-9 cell proliferation in a dose-dependent manner, with PC-9 cells containing a deletion mutation in exon 19 of the EGFR gene. Erlotinib treatment also did not affect SBC-5 cell migration. Erlotinib inhibited HPAC and Capan-1 cell growth with IC50 of 1.1 and 3 µm, respectively. 10 uM Erlotinib inhibits EGFR phosphorylation at Y845 (Src-dependent phosphorylation) and Y1068 (autophosphorylation) sites. Erlotinib inhibits extracellular signal-regulated kinases, Akt, and S6 only in the most sensitive cell lines.
In vivo studyErlotinib alone inhibits tumor growth in the H460a tumor model in a dose-dependent manner and is related to circulating levels of the drug.

ERLOTINIB HCL SALT - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
HS Code29335990
ERLOTINIB HCL SALT
Supplier List
Shanghai Macklin Biochemical Co., Ltd
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CAS: 183319-69-9
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Shanghai Amole Biotechnology Co., Ltd.
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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MedChemExpress (MCE)
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CAS: 183319-69-9
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BOC Sciences
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SKYRUN INDUSTRIAL CO.,LTD
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Erlotinib hydrochloride Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd
Spot supply
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Hubei Rhema Reference Materials Technology Co., Ltd.
Spot supply
Product Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine Request for quotation
CAS: 183319-69-9
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249 Click to send a QQ message
Wechat: 15787876101
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: +86-13776910623
Email: r@reformchem.com­
Mobile: +86-13776910623
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Erlotinib Hydrochloride Request for quotation
CAS: 183319-69-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Erlotinib HCl (OSI-744) Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
BOC Sciences
Spot supply
Product Name: Erlotinib hydrochloride Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Erlotinib hydrochloride Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
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View History
ERLOTINIB HCL SALT
硫化銅
METHYL N-ACETYLGLYCINATE
C.I.活性绿8
Z-GIN-GLY
2-fluoronicotin methyl ester
POTASSIUM CITRATE, MONOBASIC REAGENT
孔雀石绿
352277-86-2
Sumikacoat Fast Violet RSB
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